Acute cardiac care & resuscitation
Bleeding complications in patients with out-of-hospital cardiac arrest treated with cangrelor and oral P2Y12 inhibitors
Main finding · Bleeding Academic Research Consortium (BARC) 3-5 bleedingResult — go to the resultAdjusted odds ratio 0.79 95% CI 0.45–1.39Authors' conclusion
In patients with OHCA undergoing PCI, BARC 3-5 bleeding occurred at a similar rate in patients receiving either cangrelor and transition to an oral P2Y12 inhibitor or an oral P2Y12 inhibitor alone.
Study context
- Population
- Patients with out-of-hospital cardiac arrest (OHCA) undergoing percutaneous coronary intervention (PCI), treated with conventional cardiopulmonary resuscitation (CPR) or extracorporeal CPRincluded between January 2016 and March 2025
- Participants
- 414 patients
- Exposure
- Cangrelor and transition to an oral P2Y12 inhibitor or an oral P2Y12 inhibitor alone
- Cangrelor groupn = 267
- Oral P2Y12 inhibitor groupn = 147reference
- Outcome
- Bleeding Academic Research Consortium (BARC) 3-5 bleeding
- Follow-up
- 30 days
Main finding
As reported in the abstract
Adjusted odds ratio
0.79
95% CI 0.45–1.39
By group
Cangrelor groupvs oral P2Y12 inhibitor group
adjusted OR 0.79 (95% CI 0.45–1.39)
Observational data: associations, not effects.
Further findings
| Outcome | Cangrelor group | Oral P2Y12 inhibitor group | Adjusted OR (95% CI) | |
|---|---|---|---|---|
| Stent thrombosis, extracorporeal CPR subgroupWithout reaching statistical significance | 2.1% | 4.5% | 0.32 (0.03–3.14) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Bleeding Academic Research Consortium (BARC) 3-5 bleeding, conventional and extracorporeal CPR subgroups · 6, 24 and 48 h
- Similar between the cangrelor group and the oral P2Y12 inhibitor group
Original publication
Bleeding complications in patients with out-of-hospital cardiac arrest treated with cangrelor and oral P2Y12 inhibitors. Eur Heart J Acute Cardiovasc Care. Published 6 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →