Arrhythmias & electrophysiologyCohort study
Bleeding risk assessment in patients with new-onset atrial fibrillation after coronary surgery: a proof-of-concept study
- observational cohort study
- proof-of-concept
Authors' conclusion
A bleeding risk score can be used to stratify patients with POAF after CABG into groups with different post-discharge bleeding risk. Further studies are necessary to identify the optimal risk score and its role in oral anticoagulation decision pathway to improve clinical outcomes.
Study context
- Population
- Patients with new-onset post-operative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) in 2009–2020 without oral anticoagulationpatients with POAF after CABG without oral anticoagulation
- Participants
- 4,436 patients
- Exposure
- Associations between bleeding risk and major bleeding events during the first post-operative year
Main finding
As reported in the abstract
Major bleeding · first year
Major bleeding, all patients
2.1%
Observational data: associations, not effects.
Further findings
| Outcome | hazard ratio (95% CI) | |
|---|---|---|
| Major bleeding by bleeding risk category · first post-operative year | 4.81 (2.59–8.96) | |
| 0.10.31310Hazard ratio (log scale) |
High bleeding risk classification
- Patients classified as high bleeding risk
- 36.0%
Discrimination
- Area under the receiver operating characteristic curve
- 0.68 (95% CI 0.63-0.73)
Calibration
- Good agreement between expected and observed bleeding events in patients with an annual bleeding risk up to 7%
Original publication
Bleeding risk assessment in patients with new-onset atrial fibrillation after coronary surgery: a proof-of-concept study. Eur Heart J Cardiovasc Pharmacother. Published 16 June 2026. doi:10.1093/ehjcvp/pvag040
Summarised from the published abstract; every number is checked against it