Prevention & lipidsMeta-analysis
Blood DNA methylation signature of diet quality and association with cardiometabolic traits
- Meta-analysis of epigenome-wide association studies with Mendelian randomization
- 4 cohorts
- Spain, US, UK
Authors' conclusion
Diet quality in adults was related to differential methylation in blood at 18 CpGs, some of which related to cardiometabolic health.
Study context
- Population
- Adults in four cohorts from Spain, the US and the UK
- Participants
- 5,274 adults · 4 cohorts
- Comparison
- Diet quality scores and blood DNA methylation
- Outcome
- CpGs whose blood DNA methylation is associated with diet quality scores
Pooled result
As reported in the abstract
Diet-associated differentially methylated CpGs
Differentially methylated cytosine-phosphate-guanine (CpGs) associated with dietary scores
18
Of these, previously associated with cardiometabolic traits
12
Further pooled results
Pathway enrichment
- Diet-associated genes overrepresented in inflammation and CVD pathways
Mendelian randomization: diet-related CpGs and cardiometabolic traits
- Methylation for lower diet quality at cg02079413 (SNORA54), cg02107842 (MAST4), cg23761815 (SLC29A3) causally associated with higher body mass index (BMI)
- Methylation for lower diet quality at cg05399785 (WDR8) causally associated with greater systolic blood pressure (SBP)
- Methylation for higher diet quality at cg00711496 (PRMT1) associated with lower BMI, T2DM risk and coronary heart disease (CHD) risk
- Methylation for higher diet quality at cg0557921 (AHRR) associated with lower CHD risk
Original publication
Blood DNA methylation signature of diet quality and association with cardiometabolic traits. Eur J Prev Cardiol. Published 4 October 2023. doi:10.1093/eurjpc/zwad317
Summarised from the published abstract; every number is checked against it