Cohort study
Blood Levels of Angiotensinogen and Hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA)
- Cohort study
- multi-ethnic
- sex-balanced
Authors' conclusion
Significant differences in angiotensinogen levels are present between sexes and ethnicities. A positive association is present between levels and prevalent hypertension and BP, which differs between sexes.
Study context
- Population
- Sex-balanced, ethnically diverse cohort (MESA)
- Participants
- 5,786 participants
- Exposure
- Males vs Females
- Outcome
- Association of plasma angiotensinogen with BP, prevalent hypertension and incident hypertension
Main finding
As reported in the abstract
SBP per SD increment in log-angiotensinogen, by sex (no RAAS-blocking medications)
Difference, mm Hg (95% CI)
Males
2.61(1.49–3.80)
Females
0.97(0.30–1.65)
Per SD increment in log-angiotensinogen, as printed
Observational data: associations, not effects.
Further findings
Angiotensinogen levels by sex and ethnicity
- Significantly higher in females than males
- Differed across self-reported ethnicities, highest to lowest: White, Black, Hispanic, Chinese adults
Original publication
Blood Levels of Angiotensinogen and Hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA). J Am Coll Cardiol. Published 4 April 2023. doi:10.1016/j.jacc.2023.01.033
Summarised from the published abstract; every number is checked against it