Blood Pressure and Cardiovascular Risk in Women With Breast Cancer: The Pathways Heart Study
Authors' conclusion
Women with and without BC showed similar risks for IHD, stroke, and any primary CVD
Study context
- Population
- Women with invasive breast cancer diagnosed 2005–2013 at Kaiser Permanente Northern California, matched 1:5 to women without breast cancer (BC)
- Participants
- 12,713 vs 55,886
- Exposure
- Association of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with cardiovascular disease (CVD) outcomes in women with BC vs without BC
- BC casesn = 12,713
- Controlsn = 55,886reference
- Outcome
- Association of SBP and DBP with CVD outcomes (IHD, stroke, HF/cardiomyopathy, any primary CVD)
- Follow-up
- Median 9.6 years (IQR: 5.0-11.9 years)
Methodological detailsKaiser Permanente Northern California, electronic health records, BC cases: mean age 60.6 years; 64.8% non-Hispanic White
- Kaiser Permanente Northern California
- Electronic health records
- BC cases: mean age 60.6 years; 64.8% non-Hispanic White
Main finding
As reported in the abstract
CVD risk per 10 mmHg increase in BP, women with BC
- Ischemic heart disease (IHD) per 10 mmHg increase in SBP (BC)
- 1.23 (95% CI: 1.14-1.33)
- IHD per 10 mmHg increase in DBP (BC)
- 1.10 (95% CI: 0.98-1.24)
- Stroke per 10 mmHg increase in SBP (BC)
- 1.45 (95% CI: 1.34-1.58)
- Stroke per 10 mmHg increase in DBP (BC)
- 1.91 (95% CI: 1.68-2.18)
- Risks varied by BC status for HF/cardiomyopathy
- P for interaction = 0.01
Observational data: associations, not effects.
Original publication
Blood Pressure and Cardiovascular Risk in Women With Breast Cancer: The Pathways Heart Study. JACC Adv. Published 14 August 2024. doi:10.
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