Heart failure & cardiomyopathiesSecondary analysis
Blood Pressure and Intensive Treatment Up-Titration After Acute Heart Failure Hospitalization: Insights from the STRONG-HF Trial
- Secondary analysis of the STRONG-HF randomised trial
- post-hoc analysis
Authors' conclusion
In STRONG-HF, the benefits of HIC versus UC were independent of baseline SBP. Rapid GDMT up-titration was performed also in patients with an early SBP drop, resulting in similar 180-day outcome as compared to patients with stable or increased SBP.
Study context
- Population
- Patients hospitalised for acute HF with systolic blood pressure (SBP) ≥100 mmHg
- Participants
- 1,075 patients
- Comparison
- High-intensity care (HIC) vs usual care (UC) by baseline SBP tertiles; early SBP change within HIC
- Primary endpoint
- 180-day heart failure rehospitalization or death
- Follow-up
- 180 days
Primary result
As reported in the abstract
HIC vs UC effect on primary endpoint by baseline SBP (tertiles <118, 118-128, ≥129 mmHg)
Effect of HIC vs UC independent of baseline SBP as tertiles
pinteraction = 0.77
Effect of HIC vs UC independent of baseline SBP as continuous variable
pinteraction = 0.91
Further findings
Target GDMT doses reached at day 90, HIC arm, by SBP change at 1 week
Primary endpoint by SBP change at 1 week, HIC arm · 180 days
- Risk not significantly different between SBP-change groups
- adjusted p = 0.46
Original publication
Blood Pressure and Intensive Treatment Up-Titration After Acute Heart Failure Hospitalization: Insights from the STRONG-HF Trial. Eur J Heart Fail. Published 5 March 2024. doi:10.1002/ejhf.3174
Summarised from the published abstract; every number is checked against it