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HypertensionCohort study

Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum

JAMA CardiolPublished

  • Prospective cohort study
  • 8 US clinical sites
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Authors' conclusion

Results of this cohort study reveal that higher SBP genetic risk was independently associated with higher risk of developing new-onset hypertension 2 to 7 years after delivery. However, HDP history and elevated BMI were more important contributors to hypertension risk.

Study context

Population
Genotyped women without pregestational chronic hypertension enrolled during first pregnancy 2010–2013 (nuMoM2b Heart Health Study)353 [12.4%] with prior hypertensive disorders of pregnancy (HDP)
Participants
2,852 women
Exposure
High vs low systolic blood pressure (SBP) genetic risk
Outcome
Stage 1+ hypertension (≥130/80 mm Hg or antihypertensive medication)
Follow-up
2 to 7 years post partum

Main finding

Incident hypertension

Adjusted odds ratio

1.50

95% CI 1.09–2.07

P = 0.01

High vs Low
aOR 1.50 (95% CI 1.09–2.07); P = 0.01

As reported in the abstract

Developed hypertension (all participants)
509 (17.8%)

Observational data: associations, not effects.

Further findings

OutcomeaOR (95% CI)P value
Incident hypertension, by HDP history (subgroup), per SD of SBP genetic risk — SBP genetic risk per SD · without prior HDP1.25 (1.12–1.40)P < 0.001
Incident hypertension, by HDP history (subgroup), per SD of SBP genetic risk — SBP genetic risk per SD · with prior HDP1.01 (0.79–1.28)P = 0.92
  • Incident hypertension, by HDP history (subgroup), per SD of SBP genetic risk: P for interaction = .10

Population attributable risk for hypertension

High SBP genetic risk
4.7%
HDP history
10.8%
Body mass index (BMI) ≥25
41.5%

Original publication

Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum. JAMA Cardiol. Published 1 May 2026. doi:10.1001/jamacardio.2026.0363
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Summarised from the published abstract; every number is checked against it