HypertensionMeta-analysis
Blood pressure, hypertension, and the risk of heart failure: a systematic review and meta-analysis of cohort studies
- Systematic review and meta-analysis of cohort studies
- random-effects models
Authors' conclusion
This meta-analysis suggests a strong positive association between hypertension and systolic and diastolic blood pressure and the risk of heart failure.
Study context
- Population
- Cohort studies of hypertension or BP and HF; PubMed and Embase to 10 June 202247 cohort studies
- Comparison
- Hypertension vs no hypertension; per increment of SBP and DBP
- Outcome
- HF risk
Pooled result
As reported in the abstract
Heart failure
Summary RR (95% CI)
hypertension vs no hypertensionI2 = 98.4%; 43 studies, 166 798 cases, 20 359 997 participants
1.71(1.53–1.90)
per 20 mmHg of systolic blood pressureI2 = 90.3%; 24 studies, 31 639 cases, 2 557 975 participants
1.28(1.22–1.35)
per 10 mmHg of diastolic blood pressureI2 = 92.6%; 16 studies, 23 127 cases, 2 419 972 participants
1.12(1.04–1.21)
Further pooled results
Dose-response of HF risk by BP level
- Steeper increase in HF risk at higher BP; three- to five-fold increase in RR at around 180/120 vs 100/60 mmHg
Publication bias
- Little indication of publication bias across analyses
Original publication
Blood pressure, hypertension, and the risk of heart failure: a systematic review and meta-analysis of cohort studies. Eur J Prev Cardiol. Published 6 November 2023. doi:10.1093/eurjpc/zwad344
Summarised from the published abstract; every number is checked against it