Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial
Primary result · All-cause dementiaResult — go to the resultRisk ratio 0.85 95% CI 0.76–0.95Authors' conclusion
This cluster-randomized trial indicates that intensive BP reduction is effective in lowering the risk of all-cause dementia in patients with hypertension.
Study context
- Population
- Individuals aged ≥40 years with uncontrolled hypertension in rural China163 + 163 villages randomised
- Participants
- 33,995 individuals
- Comparison
- Intervention vs Usual care
- Interventionn = 163 villages
- Usual caren = 163 villagesreference
- Primary endpoint
- All-cause dementia
Methodological detailsopen-label, blinded-endpoint
- Open-label
- Blinded-endpoint
Primary result
All-cause dementia
Risk ratio
0.85
95% CI 0.76–0.95
P = 0.0035
Intervention vs Usual care
risk ratio 0.85 (95% CI 0.76–0.95); P = 0.0035
As reported in the abstract
Further findings
| Outcome | Net reduction (mm Hg) (95% CI) | P value | |
|---|---|---|---|
| Net reduction in SBP · 48 months | 22.0 (20.6–23.4) | P < 0.0001 | |
| Net reduction in DBP · 48 months | 9.3 (8.7–10.0) | P < 0.0001 | |
| −100102030Difference, mm Hg (linear scale) |
Safety
| Outcome | Risk ratio (95% CI) | P value | |
|---|---|---|---|
| Serious adverse events · less frequent with intervention | 0.94 (0.91–0.98) | P = 0.0006 | |
| 0.512Risk ratio (log scale) |
Original publication
Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial. Nat Med. Published 21 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it