Coronary disease & ACSCohort study
Body mass index and major cardiovascular events after myocardial infarction: a nationwide registry study
- Registry-based cohort study
- nationwide
Authors' conclusion
Obesity was associated with increased risk of MACE, partly mediated by obesity-related risk factors.
Study context
- Population
- Patients hospitalised with myocardial infarction (MI), SWEDEHEART registry, 2010–2021
- Participants
- 173,617 patients
- Exposure
- Body mass index (BMI) categories vs BMI 20 to <25 kg/m²
- Outcome
- MACE:
- Recurrent MI
- Stroke
- HF hospitalisation
- CV death
- Follow-up
- Median 3.3 years
Main finding
As reported in the abstract
MACE
Adjusted hazard ratio (95% CI)
Overweight vs 20 to <25 kg/m²
0.99(0.97–1.01)
Obesity class I vs 20 to <25 kg/m²increasing across higher obesity classes
1.17(1.14–1.20)
- Major adverse cardiovascular events (MACE) during follow-up (whole cohort)
- 36.5%
Observational data: associations, not effects.
Further findings
Mediation of excess risk
- Excess risk largely mediated by diabetes, hypertension and prior CVD
Original publication
Body mass index and major cardiovascular events after myocardial infarction: a nationwide registry study. Eur J Prev Cardiol. Published 5 August 2026. doi:10.1093/eurjpc/zwag410
Summarised from the published abstract; every number is checked against it