Heart failure & cardiomyopathiesCohort study
Body mass index, regional adipose deposition, and clinical outcomes in non-ischaemic dilated cardiomyopathy: a prospective cohort study
- Prospective cohort study
Authors' conclusion
Lower BMI and thinner regional adipose tissue represented the worse clinical phenotype and adverse remodelling and were associated with worse clinical outcomes in patients with DCM.
Study context
- Population
- Patients with non-ischaemic dilated cardiomyopathy (DCM)
- Participants
- 1,042 patients
- Exposure
- Body mass index (BMI) and regional adipose tissue by CMR vs clinical outcomes
- Outcome
- All-cause mortality and heart transplantation (HTX)
- Follow-up
- Median 41 months
Main finding
As reported in the abstract
All-cause mortality or HTX
Primary endpoint events
237
BMI, independent predictor (HR)
0.94, 95% CI 0.90-0.98, P = 0.006
Visceral adipose tissue (VAT) thickness per 1 mm, independent predictor (HR)
0.94, 95% CI 0.91-0.97, P < 0.001
Epicardial adipose tissue (EAT) volume per 1 mL, independent predictor (HR)
0.96, 95% CI 0.95-0.97, P < 0.001
Observational data: associations, not effects.
Further findings
HF death/HTX
- EAT volume had the highest predictive value (C-index)
- 0.70
Arrhythmia endpoint
- BMI was the best predictor (C-index)
- 0.64
Baseline phenotype
- Underweight patients: more often women, lower BP, worse NYHA class, reduced biventricular EF, higher native T1 and extracellular volume fraction
- Reduced regional adipose tissue associated with adverse remodelling, worse cardiac function and higher diffuse myocardial fibrosis
Original publication
Body mass index, regional adipose deposition, and clinical outcomes in non-ischaemic dilated cardiomyopathy: a prospective cohort study. Eur J Prev Cardiol. Published 28 January 2025. doi:10.1093/eurjpc/zwaf028
Summarised from the published abstract; every number is checked against it