Cardiometabolic & kidneySecondary analysis
Body weight time in target range and cardiovascular outcomes in adults with overweight/obesity and type 2 diabetes
- Secondary analysis of the Look AHEAD randomised trial
Authors' conclusion
In adults with overweight/obesity and type 2 diabetes, higher body weight TTR was independently associated with lower risks of cardiovascular adverse events in a dose-response manner.
Study context
- Population
- Adults with overweight/obesity and T2DM
- Participants
- 4,468 adults
- Comparison
- Body weight time in target range (TTR)
- Primary endpoint
- Primary CV outcome
- Follow-up
- Median 9.5 years
Primary result
As reported in the abstract
Primary outcome per 1 SD increase in body weight TTR
Hazard ratio
0.84
95% CI 0.75–0.94
Each 1 SD increase in body weight TTR
HR 0.84 (95% CI 0.75–0.94)
Each 1 SD increase in body weight TTR, as printed
- Incident primary outcomes
- 721
- Cumulative incidence of primary outcome
- 17.5% (95% CI 16.3-18.8%)
Further findings
Primary outcome in participants with lower baseline or mean body weight (subgroup)
- Similar associations remained significant
Original publication
Body weight time in target range and cardiovascular outcomes in adults with overweight/obesity and type 2 diabetes. Eur J Prev Cardiol. Published 22 May 2023. doi:10.1093/eurjpc/zwad165
Summarised from the published abstract; every number is checked against it