Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets
Authors' conclusion
BCAA catabolism is an important regulator of platelet activation and is associated with arterial thrombosis risk.
Study context
- Population
- Healthy human subjects; PP2Cm-deficient mice; ob/ob mice; patients with T2DM
- Comparison
- BCAA ingestion vs before ingestion; PP2Cm-deficient vs wild-type platelets
- Outcome
- Effects of BCAA ingestion/catabolism on platelet activity and arterial thrombosis
Main finding
As reported in the abstract
- BCAA ingestion significantly promoted human platelet activity (n=5)
- P<0.001
- BCAA ingestion promoted arterial thrombosis formation in mice (n=9)
- P<0.05
- Protein phosphatase 2Cm deficiency significantly suppressed platelet activity in response to agonists (n=5)
- P<0.05
- Lowering dietary BCAA intake significantly reduced platelet activity in ob/ob mice (n=4)
- P<0.05
Original publication
Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets. Circulation. Published 23 March 2020. doi:10.
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