Prevention & lipidsCohort study
Breast Artery Calcification for Primary Prevention of Major Adverse Cardiovascular Outcomes in Women
- retrospective cohort study
- consecutive women
- Dartmouth Health
- 2011 to 2012
- 10 years of follow-up
Authors' conclusion
The use of the pooled cohort equations to risk stratify women for MACE underestimates risk in women with a low predicted risk. BAC is independently associated with an increased risk of MACE and may be useful as an incremental risk modifier.
Study context
- Population
- Women aged 40 to 75 without coronary artery disease who underwent a routine screening mammogram
- Participants
- 1,216 women
- Exposure
- Women with breast artery calcification (BAC) vs women without BAC
- BACn = 232
Main finding
As reported in the abstract
Major adverse cardiovascular events (MACE) · 10 years
P < 0.001
Observational data: associations, not effects.
Further findings
Incidence
| Outcome | BAC | without BAC | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| MACE among women with low (<5%) risk by pooled cohort equations (subgroup) | 18% | 7% | 2.8 (1.5–5.0) | P = 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Breast Artery Calcification for Primary Prevention of Major Adverse Cardiovascular Outcomes in Women. JACC Adv. Published 29 April 2026. doi:10.1016/j.jacadv.2026.102737
Summarised from the published abstract; every number is checked against it