Pulmonary vascular disease & thromboembolismCohort study
Burden and long-term impact of pulmonary embolism on health-related quality of life: a matched cohort study
- Matched cohort study
- prospective multicenter
- matched on age, sex and key comorbidities
- multiple imputation and complete case analysis
Authors' conclusion
PE was independently associated with a moderate decrease in HrQoL, which persisted 12 months after the acute episode despite partial recovery over time.
Study context
- Population
- Patients after acute pulmonary embolism (PE) from a prospective multicenter studymatched cohort
- Participants
- 1,005 vs 3,058
- Exposure
- PE survivors vs matched general-population controls
- PEn = 1,005
- Controlsn = 3,058reference
- Outcome
- HrQoL (EQ-5D-5L dimensions and HrQoL index, range 0 to 1)
- Follow-up
- 3 and 12 months
Main finding
As reported in the abstract
HrQoL index
PE vs ControlsAdjusted difference (95% CI)
3 months; range 0 to 1
−0.04(−0.06 to −0.039)
12 months
−0.02(−0.04 to −0.01)
Observational data: associations, not effects.
Further findings
Annual disability weight of PE for DALY calculation
- Conservatively estimated disability weight
- 0.03 (95% CI: 0.02, 0.04)
Original publication
Burden and long-term impact of pulmonary embolism on health-related quality of life: a matched cohort study. Eur J Prev Cardiol. Published 14 May 2025. doi:10.1093/eurjpc/zwaf307
Summarised from the published abstract; every number is checked against it