Arrhythmias & electrophysiologyCohort study
Burden of cardiometabolic disorders and lifetime risk of new-onset atrial fibrillation among men and women: the Rotterdam Study
- Prospective cohort study
- population-based
Authors' conclusion
We observed a significant combined impact of cardiometabolic disorders on AF risk, in particular among women. Participants with cardiometabolic multimorbidity had a significantly higher lifetime risk of AF, especially at a young index age.
Study context
- Population
- Men and women free of atrial fibrillation (AF) at baseline (1996–2008), population-based Rotterdam Study4,101 men · 5421 women
- Exposure
- Burden of cardiometabolic disorders, by sex
- Outcome
- New-onset AF and remaining lifetime risk of AF
- Follow-up
- Median 12.8 years
Main finding
As reported in the abstract
New-onset AF per larger burden of cardiometabolic disorders
HR
Larger burden (women)women; fully adjusted
1.33(95% CI 1.22–1.46)
Larger burden (men)men; fully adjusted
1.18(CI 1.08–1.29)
Per larger burden of cardiometabolic disorders, as printed
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Lifetime risk of AF, men, by number of disorders · index age 55 years | 0 27.1% (95% CI 20.8–33.4) · 1 26.5% (95% CI 22.8–30.5) · 2 29.9% (95% CI 26.7–33.2) · 3 30.8% (95% CI 25.7–35.8) · ≥4 33.3% (95% CI 23.1–43.6) |
| Lifetime risk of AF, women, by number of disorders · index age 55 years | 0 15.8% (95% CI 10.5–21.2) · 1 23.0% (95% CI 19.8–26.2) · 2 29.7% (95% CI 26.8–32.6) · 3 26.2% (95% CI 20.8–31.6) · ≥4 34.2% (95% CI 17.3–51.1) |
Original publication
Burden of cardiometabolic disorders and lifetime risk of new-onset atrial fibrillation among men and women: the Rotterdam Study. Eur J Prev Cardiol. Published 2 February 2024. doi:10.1093/eurjpc/zwae045
Summarised from the published abstract; every number is checked against it