Heart failure & cardiomyopathiesCohort study
Burden of chronic kidney disease and outcomes following hospitalisation for heart failure
- 5-year longitudinal cohort analysis
- patients enrolled in the Patient Centered Care Transitions in heart failure (HF) randomised controlled trial
- linked, administrative databases
- Cox-proportional hazards models adjusted for baseline variables
Authors' conclusion
CKD is common at index hospitalisation for HF and is associated with a higher risk of death, shorter lifespan, more rehospitalisations and nearly twice the direct healthcare costs than no CKD. A vast majority of patients without CKD at index hospitalisation for HF are diagnosed with it subsequently.
Study context
- Population
- Patients hospitalised for HFpatients hospitalised for HF, 929 (20.9%) had an established chronic kidney disease (CKD) diagnosis at index hospitalisation
- Participants
- 4,441 patients
- Exposure
- those with and without a CKD diagnosis at index hospitalisation
- CKDn = 929
Main finding
Death
Adjusted hazard ratio
1.55
95% CI 1.42–1.69
As reported in the abstract
Observational data: associations, not effects.
Further findings
Survival
Rehospitalisations
In-hospital days
| Outcome | CKD | No CKD |
|---|---|---|
| Annual healthcare costs | mean $C128 840 (SD 137 611) $C/year | mean $C67 937 (SD 104 149) $C/year |
Ambulatory and diagnostic services; ACE inhibitor or mineralocorticoid receptor antagonist dispensing
- CKD received more ambulatory and diagnostic services and were less likely to be dispensed an ACE inhibitor or mineralocorticoid receptor antagonist
- after adjusting for relevant baseline characteristics
Annual healthcare costs
- nearly two times as high, largely due to rehospitalisations
CKD diagnosis during follow-up among those without CKD at baseline · follow-up period
- received a CKD diagnosis during follow-up (of those without CKD at baseline)
- at least 83.4%
Original publication
Summarised from the published abstract; every number is checked against it