Heart failure & cardiomyopathiesCohort study
C-Reactive Protein and Risk of Incident Heart Failure in Patients With Cardiovascular Disease
- Prospective cohort study
Authors' conclusion
In patients with established CVD, CRP is an independent risk marker of incident HF.
Study context
- Population
- Patients with established cardiovascular disease (CVD) without prevalent heart failure (HF) (UCC-SMART cohort)
- Participants
- 8,089 patients
- Exposure
- Higher vs lower baseline C-reactive protein (CRP)
- Outcome
- Incident HF (first hospitalization for HF)
- Follow-up
- Median 9.7 years (IQR 5.4-14.1 years)
Main finding
As reported in the abstract
Incident HF · median follow-up 9.7 years
Hazard ratio (95% CI)
CRP per 1 mg/L
1.10(1.07–1.13)
Last CRP quartile vs First CRP quartile
2.22(1.76–2.79)
- Incident HF cases
- 810
- Incidence rate
- 1.01/100 person-years
Observational data: associations, not effects.
Further findings
Incident HF by EF type (CRP association)
| Comparison | HR (95% CI) | |
|---|---|---|
| HF with reduced · HFrEF | 1.09 (1.04–1.14) | |
| preserved ejection fraction · HFpEF | 1.12 (1.07–1.18) | |
| 0.512Hazard ratio (log scale) |
- Incident HF by EF type (CRP association): P for difference = 0.137
Sensitivity analyses
- Additional adjustment for medication use and interim MI did not attenuate the association; consistent beyond 15 years after CRP measurement
Original publication
C-Reactive Protein and Risk of Incident Heart Failure in Patients With Cardiovascular Disease. J Am Coll Cardiol. Published 1 August 2023. doi:10.1016/j.jacc.2023.05.035
Summarised from the published abstract; every number is checked against it