Heart failure & cardiomyopathiesMeta-analysis
Calcium Channel Blocker Use and Outcomes in Patients with Heart Failure and Mildly Reduced and Preserved Ejection Fraction
- Pooled analysis of individual patient data from four randomised trials
- observational analysis of non-randomized treatment
Authors' conclusion
Although this is an observational analysis of non-randomized treatment, there was no suggestion that CCBs were associated with worse HF outcomes. Indeed, CCB use was associated with a lower incidence of pump failure death.
Study context
- Population
- Patients with HFmrEF/HFpEF from four large trials
- Participants
- 16,954 patients · 4 trials
- Comparison
- CCB use vs no CCB
- CCBn = 5,874
Pooled result
As reported in the abstract
Death, HF hospitalization, pump failure death, stroke
CCB vs No CCBHazard ratio (95% CI)
pump failure death
0.76(0.60–0.96)
stroke
1.26(1.06–1.50)
Further pooled results
Outcomes by CCB subtype (dihydropyridine vs non-dihydropyridine)
- Pattern of outcomes broadly similar for both subtypes
Original publication
Calcium Channel Blocker Use and Outcomes in Patients with Heart Failure and Mildly Reduced and Preserved Ejection Fraction. Eur J Heart Fail. Published 5 October 2023. doi:10.1002/ejhf.3044
Summarised from the published abstract; every number is checked against it