Optical Coherence Tomography (OCT) vs Angiography for Guidance of Percutaneous Coronary Intervention of Calcified Lesions: The CALIPSO Randomized Clinical Trial
Authors' conclusion
The CALIPSO randomized clinical trial showed that OCT guidance associated with predefined algorithmic management achieved better stent implantation results than angiography guidance in patients with calcified lesions PCI, without any additional safety concern.
Study context
- Population
- Patients with stable moderate to severe calcified coronary lesions scheduled for percutaneous coronary intervention (PCI)134 analysed
- Participants
- 143 patients
- Comparison
- OCT-guided PCI vs angiography-guided PCI
- OCTn = 65
- Angiographyn = 69reference
- Primary endpoint
- Minimal stent area (MSA) measured by OCT
Methodological detailsprospective, multicentre, open-label, 12 sites in France, Conducted December 2021 to June 2023
- Prospective
- Multicentre
- Open-label
- 12 sites in France
- Conducted December 2021 to June 2023
Primary result
As reported in the abstract
Final MSA
P < 0.001
Further findings
Use of intravascular lithotripsy
P < 0.001
Safety
Periprocedural complications, contrast medium volume, procedure duration
- No difference between groups
Original publication
OCT vs Angiography for Guidance of Percutaneous Coronary Intervention of Calcified Lesions: The CALIPSO Randomized Clinical Trial. JAMA Cardiol. Published 1 July 2025. doi:10.
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