Arrhythmias & electrophysiologyMeta-analysis
CAMERA-MRI score to predict left ventricular ejection fraction normalization post-ablation for primary atrial fibrillation-mediated cardiomyopathy: A pooled analysis of two randomized clinical trials
- pooled analysis of the CAMERA-MRI and CAMERA-MRI II multicenter randomized trials
- internally validated through bootstrap resampling (200 iterations) and 5-fold cross-validation
- univariable and multivariable logistic regression
Authors' conclusion
Absence of late gadolinium enhancement, normal LV volumes, and absence of an alternative etiology identified that the AF-induced cardiomyopathy phenotype is most likely to achieve LVEF normalization following catheter ablation.
Study context
- Population
- Patients with atrial fibrillation (AF)-mediated cardiomyopathy who underwent catheter ablation, with baseline and serial cardiac magnetic resonancepatients included, 70 (63.7%) achieved left ventricular ejection fraction (LVEF) normalization
- Participants
- 113 patients
- Comparison
- Predictors of LVEF normalization following catheter ablation
Pooled result
As reported in the abstract
Independent predictors of LVEF normalization (multivariable analysis)
Odds ratio (95% CI)P value
normal indexed LV end-diastolic volume
3.20(1.20–8.56)
P = 0.021absence of alternate etiology
4.31(1.14–16.39)
P = 0.023absence of late gadolinium enhancement
2.53(1.01–6.39)
P = 0.049Further pooled results
Score model performance
- area under the curve
- 0.788 (95% CI, 0.703-0.873)
Normalization likelihood by score
- score 0/3
- 12%
- score 1/3
- 38%
- score 2/3
- 67%
- score 3/3
- 88%
Original publication
CAMERA-MRI score to predict left ventricular ejection fraction normalization post-ablation for primary atrial fibrillation-mediated cardiomyopathy: A pooled analysis of two randomized clinical trials. Heart Rhythm. Published 14 July 2026. doi:10.1016/j.hrthm.2026.07.015
Summarised from the published abstract; every number is checked against it