Cardio-oncology & otherMechanistic study
Cancer Therapy-related Cardiotoxicity is Associated with Distinct Alterations of the Myocardial Lipidome
- Mechanistic study
- untargeted mass spectrometry-based lipidomics
- age- and sex-matched controls
Authors' conclusion
Anthracycline-induced cardiotoxicity leads to distinct alterations of the myocardial lipidome. Increased levels of myocardial lysolipids were identified as a novel lipidomic trait in AIC, which appears to be distinct from other causes of heart failure.
Study context
- Population
- Myocardial biopsies from patients with anthracycline-induced cardiotoxicity (age 53 ± 31 years, 54% female, LVEF 19 ± 4%)
- Participants
- 13 / 15 / 15
- Comparison
- Anthracycline-induced cardiotoxicity (AIC) vs matched controls and other HF aetiologies
- AICn = 13
- Controlsn = 15reference
- Other heart failure aetiologiesn = 15
Main finding
As reported in the abstract
Myocardial lipidome (627 lipid species, 22 classes)
- AIC: lower proportion of polyunsaturated fatty acids, towards more monounsaturated and saturated sidechains
- AIC: significant alterations in the proportion of odd-chain fatty acids
- AIC: higher precursor conversion into lysolipids (pathway analyses)
- Lysolipid accumulation not observed in other HF aetiologies
Original publication
Cancer Therapy-related Cardiotoxicity is Associated with Distinct Alterations of the Myocardial Lipidome. Eur J Heart Fail. Published 1 May 2025. doi:10.1002/ejhf.3656
Summarised from the published abstract; every number is checked against it