Heart failure & cardiomyopathiesCohort study
Cardiac allograft vasculopathy and secondary outcomes at 1-year in heart transplantation from circulatory death donors
- registry analysis using unadjusted and adjusted logistic regression with propensity-score matched cohorts
- UNOS registry
- propensity-score matched within the same heart-transplantation (HT) centers
Authors' conclusion
One-year CAV and other key secondary clinical outcomes were similar DBD and DCD-HT recipients, irrespective of DPP or NRP procurement method. Intermediate and long-term CAV risk in DCD-HT needs to be further clarified.
Study context
- Population
- Adult heart transplants performed between January 2020 and June 2024 with follow-up through June 2025, with 1-year survivaleligible transplants with 1-year survival · DBD 11,393 · DCD 1,237
- Participants
- 12,630 participants
- Exposure
- One-year cardiac allograft vasculopathy (CAV) was compared between DBD and DCD recipients
- DBDn = 11,393
- DCDn = 1,237
Main finding
1-year CAV · 1 year
Adjusted odds ratio
0.99
95% CI 0.77–1.28
P = 0.94
By group
DCD vs DBD
adjusted OR 0.99 (95% CI 0.77–1.28); P = 0.94
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | DBD | DCD | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| CAV in propensity-matched pairs from the same centers · direction of ratio not stated in abstract | 6.51% | 5.61% | 0.85 (0.60–1.21) | P = 0.37 | |
| 0.512Odds ratio (log scale) |
- CAV in propensity-matched pairs from the same centers: 1,106 propensity-matched pairs
Secondary outcomes (chronic dialysis, hospitalization for infection or rejection, impaired functional status)
- comparable
CAV risk by DCD procurement method (DPP and NRP)
- no significant differences in CAV risk
Original publication
Cardiac allograft vasculopathy and secondary outcomes at 1-year in heart transplantation from circulatory death donors. Am Heart J. Published 14 August 2026. doi:10.1016/j.ahj.2026.107574
Summarised from the published abstract; every number is checked against it