Heart failure & cardiomyopathies
Cardiac allograft vasculopathy mediates the relationship between vitamin D deficiency and cardiovascular mortality following heart transplantation
Authors' conclusion
VDD is an independent predictor of all-cause mortality, cardiovascular mortality, and presence of CAV in patients with OHT.
Study context
- Population
- Patients after orthotopic heart transplantation (OHT)
- Participants
- 327 patients
- Exposure
- Vitamin D deficiency (VDD) vs no VDD
- VDDn = 95
- Outcome
- Baseline presence of CAV and all-cause and CV mortality
- Follow-up
- 5 years
Main finding
As reported in the abstract
VDD vs No VDDEstimate (95% CI)
5-year all-cause mortality, adjusted
HR 2.08(1.20–3.60)
CV death, adjusted
SHR 2.21(1.13–4.31)
Presence of CAV, adjusted
OR 3.08(1.39–6.80)
Observational data: associations, not effects.
Further findings
Interaction VDD × cardiac allograft vasculopathy (CAV) on CV death; mediation by CAV grade
- Interaction between VDD and CAV on CV death
- P = 0.042
- CAV grade accounts for share of association between VD and CV mortality
- 26.5%
- Interaction P = .042
Original publication
Cardiac allograft vasculopathy mediates the relationship between vitamin D deficiency and cardiovascular mortality following heart transplantation. Am Heart J. Published 16 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →