Heart failure & cardiomyopathiesCohort study
Cardiac amyloidosis across the spectrum of left ventricular function: multimodal functional and prognostic insights
- cohort
- French national reference centre
- external validation in an independent, French validation cohort
Authors' conclusion
CA affects the full spectrum of LVEF phenotypes. The integration of LVEF, GLS and CIx improves prognostic stratification and argues in favour of a multimodal imaging approach for early diagnosis and individualised management.
Study context
- Population
- Patients with cardiac amyloidosis (light chain, hereditary transthyretin or wild-type transthyretin amyloidosis)patients with cardiac amyloidosis (CA) · light chain amyloidosis 557 · hereditary transthyretin amyloidosis 392 · wild-type transthyretin amyloidosis 1,137
- Participants
- 2,244 patients
- Exposure
- Left ventricular ejection fraction (LVEF) classified according to European Society of Cardiology guidelines; prognostic relevance of LVEF and its interaction with global longitudinal strain (GLS) and cardiac index (CIx)
Main finding
As reported in the abstract
LVEF phenotype distribution
patients presented with HFmrEF or HFrEF
39%
Observational data: associations, not effects.
Further findings
| Outcome | HFpEF | HFmrEF | HFrEF |
|---|---|---|---|
| Median survival time | median not reached | median 40 months | median 30 months |
Correlation of LVEF with GLS and CIx
- LVEF correlated moderately with GLS and weakly with CIx
Decision tree integrating LVEF, GLS and CIx · 4-year mortality
- four prognostic groups with HRs for 4-year mortality ranging from
- 1.6 to 3.7
Original publication
Cardiac amyloidosis across the spectrum of left ventricular function: multimodal functional and prognostic insights. Heart. Published 13 March 2026. doi:10.1136/heartjnl-2025-327260
Summarised from the published abstract; every number is checked against it