Heart failure & cardiomyopathies
Cardiac amyloidosis across the spectrum of left ventricular function: multimodal functional and prognostic insights
Authors' conclusion
CA affects the full spectrum of LVEF phenotypes. The integration of LVEF, GLS and CIx improves prognostic stratification and argues in favour of a multimodal imaging approach for early diagnosis and individualised management.
Study context
- Population
- Patients with cardiac amyloidosis (light chain, hereditary transthyretin or wild-type transthyretin amyloidosis)patients with cardiac amyloidosis (CA) · light chain amyloidosis 557 · hereditary transthyretin amyloidosis 392 · wild-type transthyretin amyloidosis 1,137
- Participants
- 2,244 patients
- Exposure
- Left ventricular ejection fraction (LVEF) classified according to European Society of Cardiology guidelines; prognostic relevance of LVEF and its interaction with global longitudinal strain (GLS) and cardiac index (CIx)
Methodological detailsFrench national reference centre, external validation in an independent, French validation cohort
- French national reference centre
- External validation in an independent, French validation cohort
Main finding
As reported in the abstract
LVEF phenotype distribution
Patients presented with HFmrEF or HFrEF
39%
Observational data: associations, not effects.
Further findings
| Outcome | HFpEF | HFmrEF | HFrEF |
|---|---|---|---|
| Median survival time | median not reached | median 40 months | median 30 months |
Correlation of LVEF with GLS and CIx
- LVEF correlated moderately with GLS and weakly with CIx
Decision tree integrating LVEF, GLS and CIx · 4-year mortality
- Four prognostic groups with HRs for 4-year mortality ranging from
- 1.6 to 3.7
Original publication
Cardiac amyloidosis across the spectrum of left ventricular function: multimodal functional and prognostic insights. Heart. Published 13 March 2026. doi:10.
Summarised from the published abstract; every number is checked against it