Heart failure & cardiomyopathiesRandomised controlled trial
Cardiac and Metabolic Effects of Dapagliflozin in Heart Failure With Preserved Ejection Fraction: The CAMEO-DAPA Trial
- Randomised controlled trial
- single-centre
- double-blind
- placebo-controlled
Authors' conclusion
In patients with HFpEF, treatment with dapagliflozin reduces resting and exercise PCWP, along with the favorable effects on plasma volume and body weight.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) (NYHA class II or III, EF ≥50%, elevated pulmonary capillary wedge pressure (PCWP) during exercise)37 completed
- Participants
- 38 patients
- Comparison
- Dapagliflozin vs placebo
- Primary endpoint
- Change from baseline in rest and peak exercise PCWP (combined, mixed-model likelihood ratio test)
- Follow-up
- 24 weeks
Primary result
As reported in the abstract
Change in PCWP at rest and during exercise
Dapagliflozin vs PlaceboETD, mm Hg (95% CI)P value
PCWP at rest
−3.5(−6.6 to −0.4)
P = 0.029PCWP at maximal exercise
−5.7(−10.8 to −0.7)
P = 0.027Secondary outcomes
| Outcome | ETD (kg) (95% CI) | P value | |
|---|---|---|---|
| Body weight | −3.5 (−5.9 to −1.1) | P = 0.006 | |
| −10−505Difference, kg (linear scale) |
| Outcome | ETD (mL) (95% CI) | P value | |
|---|---|---|---|
| Plasma volume | −285 (−510 to −60) | P = 0.014 | |
| −1000−5000500Difference, mL (linear scale) |
| Outcome | Dapagliflozin | Placebo | Estimate | P value |
|---|---|---|---|---|
| Arterial lactate at 20 W | −0.70 ± 0.77 mM | 0.37 ± 1.29 mM | P = 0.006 |
Red blood cell volume
- No significant effect on red blood cell volume
Oxygen consumption at 20 W or peak exercise
- No differences in oxygen consumption at 20 W or peak exercise
Original publication
Cardiac and Metabolic Effects of Dapagliflozin in Heart Failure With Preserved Ejection Fraction: The CAMEO-DAPA Trial. Circulation. Published 3 August 2023. doi:10.1161/circulationaha.123.065134
Summarised from the published abstract; every number is checked against it