Valvular & structural heart diseaseCohort study
Cardiac computed tomography (CT)-scan for mitral valve calcification assessment before percutaneous commissurotomy: the multicentre prospective CALCIMIT study
- prospective multicenter study
- consecutive patients
Authors' conclusion
CT-derived MVCS provides independent, reproducible prognostic information for immediate and long-term outcomes after PMC, beyond conventional echocardiographic scores. Integrating MVCS into pre-procedural assessment may improve patient selection for PMC.
Study context
- Population
- Patients with rheumatic mitral stenosis undergoing non-contrast cardiac CT before percutaneous mitral commissurotomy (PMC), 2016–2019consecutive patients (mean age 56 ± 15 years, 78% women)
- Participants
- 172 patients
- Exposure
- CT-based Mitral Valve Calcium Scoring (MVCS) as a predictor of immediate and long-term outcomes after PMC
- Outcome
- Good immediate result (GIR): final mitral valve area ≥1.5 cm² with ≥50% increase and ≤2/4 mitral regurgitation (MR)
Main finding
As reported in the abstract
Good immediate result (GIR) of PMC achieved
54.7% of patients
Observational data: associations, not effects.
Secondary outcomes
Long-term survival free of mitral reintervention (secondary endpoint)
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| MVCS · independently associated | 1.54 (1.07–2.21) | P = 0.019 | |
| 0.512Hazard ratio (log scale) |
Mitral calcification on CT
- Patients with mitral calcification
- 113 patients (66%)
MVCS threshold
- Threshold predicting both immediate and late outcomes
- 385.5 Agatston Units
Interobserver reproducibility
- Calcification detection Kappa
- 0.987
- MVCS correlation r
- 0.999
Original publication
Cardiac CT-scan for mitral valve calcification assessment before percutaneous commissurotomy: the multicentre prospective CALCIMIT study. Eur Heart J Cardiovasc Imaging. Published 23 February 2026. doi:10.1093/ehjci/jeag054
Summarised from the published abstract; every number is checked against it