Valvular & structural heart diseaseCohort study
Cardiac Damage in Early Aortic Stenosis
- Retrospective cohort study
Authors' conclusion
CD was highly prevalent in patients with mild AS. Among patients with mild AS, there was no relationship between the degree of CD and AS severity; instead, CD was highly associated with comorbidities.
Study context
- Population
- Patients with mild aortic stenosis (AS) (peak aortic valve velocity [Vmax] 2–3 m/s and abnormal aortic valve), 2010–2021
- Participants
- 9,611 patients
- Exposure
- Stage 0 vs Stage 1 vs Stage 2 vs Stage 3 vs Stage 4
- Stage 0n = 1,901
- Stage 1n = 1,613
- Stage 2n = 4,843
- Stage 3n = 891
- Stage 4n = 363
- Outcome
- Prevalence of and factors associated with cardiac damage (CD), staged by the Genereux classification
Main finding
As reported in the abstract
CD stage (Genereux classification)
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| CD stage >1 by Vmax range | Vmax <2.5 m/s 64% · Vmax ≥2.5 m/s 61% |
| CD stage >1 by number of comorbidities | 0 comorbidities 50% · 1 comorbidity 53% · 2 comorbidities 60% · 3 comorbidities 66% · 4 comorbidities 72% · ≥5 comorbidities 73% |
Cardiac damage (CD) stage >1 by Vmax range
- CD stage did not worsen with higher Vmax range
CD stage >1 by number of comorbidities
- CD stage increased with the number of comorbidities
Original publication
Cardiac Damage in Early Aortic Stenosis. JACC Cardiovasc Imaging. Published 19 June 2024. doi:10.1016/j.jcmg.2024.05.003
Summarised from the published abstract; every number is checked against it