Cardiac Effects of Long-Duration Space Flight
Authors' conclusion
The current exercise countermeasures used on the ISS appear effective in offsetting reductions in cardiac mass and volume, despite overall reductions in total cardiac work, during prolonged space flight.
Study context
- Population
- Astronauts (4 females; age 49 ± 4 years) on prolonged International Space Station (ISS) missions with current exercise countermeasures4 females
- Participants
- 13 participants
- Exposure
- Postflight vs preflight
- Outcome
- LV mass (MRI); cardiac atrophy
- Follow-up
- 3 days after flight
Methodological detailspre-post (paired) comparison
- Pre-post (paired) comparison
Main finding
As reported in the abstract
LV mass · 3 days postflight
P = 0.053
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Total cardiac work · during space flightLower during space flight | P = 0.008 |
Left ventricular (LV) stroke volume and EF
- Marginally higher LV stroke volume postflight
- P = 0.074
- Marginally higher EF postflight
- P = 0.075
Right ventricular (RV) mass, RV EF, ventricular volumes
- RV mass not different
- P = 0.999
- RV EF not different
- P = 0.147
- End-diastolic volume not different
- P = 0.934
- End-systolic volume not different
- P = 0.145
Correlations with relative change in LV mass
- Relative change in total cardiac output
- r = 0.73; P = 0.015
- Relative change in total cardiac work
- r = 0.53; P = 0.112
Original publication
Cardiac Effects of Long-Duration Space Flight. J Am Coll Cardiol. Published 22 August 2023. doi:10.
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