Cardiac Effects of Modern Breast Radiation Therapy in Patients Receiving Systemic Cancer Therapy
Authors' conclusion
Over a median of 5.1 years, modest changes in cardiac function were observed with RT. Maximum LAD dose was associated with a worsening in systolic and diastolic function parameters.
Study context
- Population
- Women with breast cancer receiving adjuvant radiation therapy (RT) (2010–2019)median follow-up 5.1 years
- Participants
- 303 women
- Outcome
- Change in echocardiographic measures of cardiac function (LVEF, longitudinal and circumferential strain, E/e', Ea/Es, RV fractional area change) and association with cardiac dose metrics
Methodological detailslongitudinal, core lab echocardiography
- Longitudinal
- Core lab echocardiography
Main finding
As reported in the abstract
5 years
Left ventricular ejection fraction (LVEF), pre-RT to 5 years (modest increase)
52.1% to 54.3%
P < 0.001
Circumferential strain, pre-RT to 5 years (worsening)
−23.7% to −21.0%
P = 0.003
Observational data: associations, not effects.
Further findings
Cardiac function, left-sided/bilateral breast cancer (subgroup)
- Changes in cardiac function across all parameters
- P < 0.05
Original publication
Cardiac Effects of Modern Breast Radiation Therapy in Patients Receiving Systemic Cancer Therapy. JACC CardioOncol. Published 4 March 2025. doi:10.
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