Cardiac energetics, oxygenation, and perfusion during increased workload in patients with type 2 diabetes mellitus
Authors' conclusion
The pre-existing energetic deficit in diabetic cardiomyopathy is exacerbated by exercise; stress PCr/ATP correlates with impaired perfusion and oxygenation.
Study context
- Population
- Patients with T2DM without significant coronary artery disease (CAD) (>50% coronary stenosis), on oral antidiabetic therapies
- Participants
- 31 vs 17
- Exposure
- T2DM vs matched controls
- T2DMn = 31
- Controlsn = 17reference
Methodological detailsmatched controls, Adenosine stress CMR for perfusion (myocardial perfusion reserve index (MPRI)) and oxygenation (blood-oxygen level-dependent (BOLD) SIΔ); cardiac phosphorus-MR spectroscopy at rest and during leg exercise
- Matched controls
- Adenosine stress CMR for perfusion (MPRI) and oxygenation (BOLD SIΔ); cardiac phosphorus-MR spectroscopy at rest and during leg exercise
Original publication
Cardiac energetics, oxygenation, and perfusion during increased workload in patients with type 2 diabetes mellitus. Eur Heart J. Published 20 September 2015. doi:10.
Summarised from the published abstract; every number is checked against it