Heart failure & cardiomyopathiesCohort study
Cardiac Function and the Effect of Heart Failure Treatment in Patients With Genotype-Positive Dilated Cardiomyopathy
- Observational cohort study
Authors' conclusion
In genotype-positive DCM/NDLVC patients with mildly reduced LVEF, the authors found a 1.8 percentage points higher LVEF in patients receiving HF treatment.
Study context
- Population
- Genotype-positive dilated cardiomyopathy (DCM)/nondilated left ventricular cardiomyopathy (NDLVC) patients in early disease stagesfollowed 3.1 years
- Participants
- 712 patients
- Exposure
- Heart failure (HF) treatment vs no HF treatment
- Outcome
- HF outcome: decline of LVEF <40% in patients with preserved or mildly reduced LVEF at baseline
Main finding
As reported in the abstract
Decline to LVEF <40% (preserved or mildly reduced LVEF at baseline, n = 407)
Declined to left ventricular ejection fraction (LVEF) <40%
24 (6%)
Observational data: associations, not effects.
Further findings
| Outcome | difference (percentage points) (95% CI) | P value | |
|---|---|---|---|
| LVEF, mildly reduced LVEF (n = 130) · higher LVEF with HF treatment · mixed model regression | 1.8 (0.7–2.9) | P = 0.01 | |
| LVEF, mildly reduced LVEF, high-risk genotypes (subgroup) · higher LVEF with HF treatment | 2.4 (0.3–4.4) | P = 0.02 | |
| −20246Difference, percentage points (linear scale) |
Original publication
Cardiac Function and the Effect of Heart Failure Treatment in Patients With Genotype-Positive Dilated Cardiomyopathy. JACC Heart Fail. Published 28 August 2026. doi:10.1016/j.jchf.2026.103367
Summarised from the published abstract; every number is checked against it