Heart failure & cardiomyopathiesCohort study
Cardiac Function, Haemodynamics, and Valve Competence with Exercise in Patients with Heart Failure with Preserved Ejection Fraction and Mild to Moderate Secondary Mitral Regurgitation
- Prospective cohort study
- consecutive enrolment
- invasive haemodynamic exercise testing with simultaneous echocardiography
Authors' conclusion
Patients with HFpEF and mild or moderate MR have more severe LV systolic dysfunction, LA myopathy, RV-PA uncoupling, and more severe pulmonary vascular disease. Mitral valve incompetence in this setting is a phenotypic marker of more advanced disease but is not a causal factor in development of HFpEF.
Study context
- Population
- Consecutive patients with heart failure with preserved ejection fraction (HFpEF) undergoing invasive haemodynamic exercise testing
- Participants
- 37 vs 145
- Exposure
- HFpEF with mild or moderate mitral regurgitation (MR) vs HFpEF without MR
- MRn = 37
- No MRn = 145reference
Main finding
As reported in the abstract
PA wedge pressure at rest · rest
P = 0.005
Observational data: associations, not effects.
Original publication
Cardiac Function, Haemodynamics, and Valve Competence with Exercise in Patients with Heart Failure with Preserved Ejection Fraction and Mild to Moderate Secondary Mitral Regurgitation. Eur J Heart Fail. Published 4 June 2024. doi:10.1002/ejhf.3322
Summarised from the published abstract; every number is checked against it