Heart failure & cardiomyopathies
Cardiac Function, Haemodynamics, and Valve Competence with Exercise in Patients with Heart Failure with Preserved Ejection Fraction and Mild to Moderate Secondary Mitral Regurgitation
Authors' conclusion
Patients with HFpEF and mild or moderate MR have more severe LV systolic dysfunction, LA myopathy, RV-PA uncoupling, and more severe pulmonary vascular disease. Mitral valve incompetence in this setting is a phenotypic marker of more advanced disease but is not a causal factor in development of HFpEF.
Study context
- Population
- Consecutive patients with heart failure with preserved ejection fraction (HFpEF) undergoing invasive haemodynamic exercise testing
- Participants
- 37 vs 145
- Exposure
- HFpEF with mild or moderate mitral regurgitation (MR) vs HFpEF without MR
- MRn = 37
- No MRn = 145reference
- Outcome
- PA wedge pressure at rest
- Follow-up
- Rest
Methodological detailsconsecutive enrolment, invasive haemodynamic exercise testing with simultaneous echocardiography
- Consecutive enrolment
- Invasive haemodynamic exercise testing with simultaneous echocardiography
Main finding
As reported in the abstract
P = 0.005
Observational data: associations, not effects.
Original publication
Cardiac Function, Haemodynamics, and Valve Competence with Exercise in Patients with Heart Failure with Preserved Ejection Fraction and Mild to Moderate Secondary Mitral Regurgitation. Eur J Heart Fail. Published 4 June 2024. doi:10.
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