Heart failure & cardiomyopathies
Cardiac imaging and biomarkers for assessing myocardial fibrosis in children with hypertrophic cardiomyopathy
Authors' conclusion
Low levels of myocardial fibrosis are common in pediatric patients with HCM seen at referral centers.
Study context
- Population
- Children with hypertrophic cardiomyopathy (HCM)52 underwent cardiac magnetic resonance imaging (cMRI)
- Participants
- 67 children
- Outcome
- Prevalence and extent of myocardial fibrosis by LGE on cardiac MRI
Methodological detailsprospective, multicentre (9 tertiary-care pediatric heart centers, US and Canada), core laboratories
- Prospective
- Multicentre (9 tertiary-care pediatric heart centers, US and Canada)
- Core laboratories
Main finding
As reported in the abstract
Myocardial fibrosis (LGE >2% of LV mass) on cMRI, non-obstructive HCM
Late gadolinium enhancement (LGE) >2% of left ventricular (LV) mass
37 (71%) of 52
%LGE, median (IQR: 6.0%, 13.0%; range 0% to 57%)
9.0%
Observational data: associations, not effects.
Further findings
Agreement of echocardiographic and cMRI measurements (LV dimensions, LV mass, septal thickness)
- Good agreement by Bland-Altman method
NT-proBNP vs cMRI measurements
- NT-proBNP strongly and positively associated with LV mass and interventricular septal thickness
- P < 0.001
- NT-proBNP not associated with LGE
Original publication
Cardiac imaging and biomarkers for assessing myocardial fibrosis in children with hypertrophic cardiomyopathy. Am Heart J. Published 12 June 2023. doi:10.
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