Cardiac mechanics in response to proteasome inhibition: a prospective study
Authors' conclusion
Inhibition of the UPS induced global deterioration of cardiac function.
Study context
- Population
- Patients with multiple myeloma receiving carfilzomib (irreversible proteasome inhibitor, Kd protocol)
- Participants
- 48 patients
- Outcome
- Cardiac mechanics (echocardiography with speckle tracking)
- Follow-up
- 3 and 6 months
Main finding
As reported in the abstract
- At 6 months: Left ventricular (LV) and RV functions additionally attenuated
- P < 0.05 for all
- Changes in proteasome activity associated with changes in global longitudinal strain (GLS), segmental LV strain and left atrial (LA) markers
- P < 0.05 for all
Observational data: associations, not effects.
Further findings
- Baseline GLS < −18% or LA strain rate > 1.71 associated with null hypertension events
Original publication
Cardiac mechanics in response to proteasome inhibition: a prospective study. Eur Heart J Cardiovasc Imaging. Published 18 August 2022. doi:10.
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