Heart failure & cardiomyopathiesDiagnostic or prognostic study
Cardiac myosin-binding protein C in community-based patients with suspected heart failure
- Diagnostic accuracy study
- multicentre
- prospective
- observational
- 5 sites
Authors' conclusion
Measurement of cMyBP-C improved the diagnostic accuracy of NT-proBNP in community-based patients with suspected HF, with greatest additive value for identifying HFrEF, and may help in the prioritization of echocardiography.
Study context
- Population
- Community-based patients with suspected HF and elevated NT-proBNP751 analysed
- Participants
- 867 patients
- Comparison
- NT-proBNP + cardiac myosin-binding protein C (cMyBP-C) vs NT-proBNP alone
- Outcome
- Diagnostic accuracy (AUROC) for HF vs no HF
Performance
As reported in the abstract
HF vs no HF
| Test or model | AUROC |
|---|---|
| NT-proBNP + cMyBP-C | 0.77 (95%CI 0.73-0.80) |
| NT-proBNP | 0.74 (0.71-0.78) |
- NT-proBNP + cMyBP-C vs NT-proBNP: P = 0.003
Further findings
| Outcome | NT-proBNP + cMyBP-C | NT-proBNP | P value |
|---|---|---|---|
| HFrEF vs no HF | P = 0.006 | ||
| AUROC | 0.90 (0.86-0.95) | 0.85 (0.80-0.90) |
HF phenotypes among analysed
- HF with reduced ejection fraction (HFrEF)
- 43 (6%)
- HFmrEF
- 75 (10%)
- HF with preserved ejection fraction (HFpEF)
- 278 (37%)
- NT-proBNP highest in HFrEF, similar patterns for hsTnT and cMyBP-C
Original publication
Cardiac myosin-binding protein C in community-based patients with suspected heart failure. Eur J Heart Fail. Published 14 July 2026. doi:10.1093/ejhf/xuag143
Summarised from the published abstract; every number is checked against it