Heart failure & cardiomyopathiesResearch article
Cardiac Myosin Inhibitors for Managing Obstructive Hypertrophic Cardiomyopathy
- Narrative review
Study context
- Population
- Patients with obstructive hypertrophic cardiomyopathy (obstructive HCM (oHCM))
Main finding
As reported in the abstract
Effects of CMIs in recent RCTs in oHCM (LVOT obstruction, exercise capacity, symptom burden)
- Cardiac myosin inhibitors (CMIs) decrease LVOT obstruction, improve exercise capacity and ameliorate symptom burden in oHCM (recent RCTs)
- Uncertain: long-term safety and efficacy, and potential to modify disease progression
Original publication
Cardiac Myosin Inhibitors for Managing Obstructive Hypertrophic Cardiomyopathy. JACC Heart Fail. doi:10.1016/j.jchf.2023.04.018
Summarised from the published abstract; every number is checked against it