Valvular & structural heart diseaseCohort study
Cardiac Remodeling After Transcatheter Tricuspid Valve Replacement
- Retrospective cohort study
- single-centre
Authors' conclusion
Reduction in RVEDV with increase in LVEDV following TTVR is associated with reduction in LV eccentricity with an increase in forward SV. CT measures of RV function (effective RVEF) and RV coupling (SV/RVESV) both improve following TTVR.
Study context
- Population
- Patients undergoing transcatheter tricuspid valve replacement (TTVR) for tricuspid regurgitation50 with paired computed tomography (CT)
- Participants
- 80 patients
- Outcome
- Biventricular structural and functional changes after TTVR (echocardiography and CT)
Main finding
As reported in the abstract
CT median 40 days post-TTVR
- Increase in effective RVEF
- 65.3%
- Increase in right ventricular (RV) coupling
- 20.3%
- Effective RVEF and RV coupling increase, P
- P < 0.001
- RVEDV decreased, mL/m² (pre to post)
- 138.2 to 59.5
- RVEDV decrease, P
- P < 0.001
- LVEDV increased, mL/m² (pre to post)
- 49.6 to 57.9
- LVEDV increase, P
- P = 0.001
- Septal curvature increased and left ventricle (LV) aEI decreased
- P < 0.001
Observational data: associations, not effects.
Further findings
Tricuspid regurgitation
- Baseline massive/torrential TR
- 87.5%
- ≤mild TR post-implantation
- 95.9%
Echocardiographic RV function, SV and cardiac index
- All echocardiographic measures of RV function reduced
- P < 0.001
- Increase in SV and cardiac index
- P < 0.001
Baseline aEI ≥1.25 vs low aEI (subgroup)
- Greater reverse remodeling, lower follow-up NT-proBNP and greater symptom improvement with baseline aEI ≥1.25
Original publication
Cardiac Remodeling After Transcatheter Tricuspid Valve Replacement. JACC Cardiovasc Interv. Published 25 November 2025. doi:10.1016/j.jcin.2025.10.023
Summarised from the published abstract; every number is checked against it