Cardio-oncology & otherCohort study
Cardiac remodelling and dysfunction in cancer patients receiving cardiotoxic therapies: proteomic and metabolomic profiling
- Prospective cohort study
- longitudinal
- proteomic and metabolomic profiling
Authors' conclusion
These findings provide translational insights into cancer therapy-related cardiac dysfunction and remodelling and identify potential new biomarkers of cardiotoxicity.
Study context
- Population
- Breast cancer patients receiving anthracyclines and/or trastuzumab
- Participants
- 547 patients
- Outcome
- Associations of circulating proteins and metabolites with echocardiographic cardiac structure (left ventricular (LV) mass, left atrial volume index) and function (LVEF, longitudinal and circumferential strain, E/e', ventricular-arterial coupling)
Main finding
As reported in the abstract
- Unique proteins associated with cardiac structure and function (contemporaneous and lagged)
- 203
- Unique metabolites associated with cardiac structure and function (contemporaneous and lagged)
- 16
- Cathepsin C associated with LV ejection fraction (LVEF)
- False discovery rate (FDR), P = .017
- Cathepsin C associated with longitudinal strain
- FDR, P = .046
- Cathepsin C associated with left atrial volume index
- FDR, P = .035
- Cathepsin C and incident cardiac dysfunction (LVEF decline ≥10% to <50%), HR (95% CI)
- .61 (.41, .90)
Observational data: associations, not effects.
Further findings
Pathway enrichment of the 147 proteins associated with cardiac function
- Enriched in protein deubiquitination, protein modification by small protein removal, macromolecule catabolic processes and global metabolic pathways
Metabolites associated with cardiac function (LVEF, longitudinal strain)
- n-acetylglutamine, aspartic acid, acetylasparagine, alanyl-alanine and prolyl-glycine (amino acids and derivatives and peptides)
- FDR, P-value < .001
Original publication
Cardiac remodelling and dysfunction in cancer patients receiving cardiotoxic therapies: proteomic and metabolomic profiling. Eur Heart J. Published 29 June 2026. doi:10.1093/eurheartj/ehag487
Summarised from the published abstract; every number is checked against it