Cardiac remodelling during pregnancy in women with congenital heart disease and systemic left ventricle
Authors' conclusion
Women with CHD had a temporal decrease in RV systolic function and RV-PA coupling, and these changes were associated with PRAO.
Study context
- Population
- Pregnant women with congenital heart disease (CHD) and systemic LV with serial echocardiograms (2003–2021)
- Participants
- 81 women
- Outcome
- Temporal changes in cardiac structure and function during pregnancy, and association with PRAO (composite of maternal CV, obstetric and neonatal complications)
- Follow-up
- Prepregnancy, early pregnancy, late pregnancy, postnatal period
Main finding
As reported in the abstract
Relative change vs baseline echocardiogram
- Right ventricular systolic pressure (RVSP) increase, early pregnancy (P < 0.001)
- 13 ± 5%
- RVSP increase, late pregnancy (P < 0.001)
- 18 ± 5%
- Right ventricle free wall strain (RVFWS) decrease, late pregnancy (P < 0.001)
- −11 ± 3%
- RVFWS decrease, postnatal period (P = 0.003)
- −11 ± 4%
- RVFWS/RVSP decrease, early pregnancy (P = 0.02)
- −10 ± 5%
- RVFWS/RVSP decrease, late pregnancy (P < 0.001)
- −26 ± 7%
- RVFWS/RVSP decrease, postnatal period (P < 0.001)
- −14 ± 5%
Observational data: associations, not effects.
Original publication
Cardiac remodelling during pregnancy in women with congenital heart disease and systemic left ventricle. Eur Heart J Cardiovasc Imaging. Published 29 July 2024. doi:10.
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