Heart failure & cardiomyopathiesRandomised controlled trial
Cardiac resynchronization therapy non-responder to responder conversion rate in the MORE-CRT MultiPoint™ Pacing (MPP) trial
- Randomised controlled trial
Authors' conclusion
MultiPoint™ Pacing does not improve CRT response in non-responders to BiVP, even with MPP-AS.
Study context
- Population
- Echocardiographic non-responders (<15% relative reduction in left ventricular end-systolic volume (LVESV)) after 6 months of standard biventricular pacing cardiac resynchronization therapy (CRT)5,850 enrolled
- Participants
- 541 vs 570
- Comparison
- MPP vs continued biventricular pacing (BiVP) in CRT non-responders
- MPPn = 541
- BiVPn = 570reference
- Primary endpoint
- Conversion rate to echocardiographic response
- Follow-up
- Additional 6 months
Primary result
As reported in the abstract
Non-responders converted to CRT responders
P = 0.743
Further findings
Conversion rate, ≥30 mm spacing between the two LV pacing sites (MPP-AS) (subgroup)
- No significant difference in the conversion rate
Original publication
Cardiac resynchronization therapy non-responder to responder conversion rate in the MORE-CRT MPP trial. Europace. Published 30 September 2023. doi:10.1093/europace/euad294
Summarised from the published abstract; every number is checked against it