Heart failure & cardiomyopathiesCohort study
Cardio-kidney-metabolic overlap in patients with severe heart failure: Data from the HELP-HF registry
- multicenter HELP-HF registry
Authors' conclusion
CKM overlap is highly prevalent among patients with severe HF and is independently associated with worse clinical outcomes. These findings underscore the importance of CKM profiling in HF risk stratification.
Study context
- Population
- Patients with severe heart failure (HF) identified by the "I NEED HELP" markerspatients enrolled in the multicenter HELP-HF registry
- Participants
- 1,149 patients
- Exposure
- Patients grouped by number of cardiovascular, kidney, and metabolic (CKM) conditions
- Outcome
- Composite of:
- All-cause death
- HF hospitalization
- Follow-up
- 1-year
Main finding
As reported in the abstract
Each group vs 0 conditionsHazard ratio (95% CI)P value
1
1.92(1.33–2.78)
P < 0.0012
2.11(1.47–3.02)
P < 0.0013
2.52(1.74–3.65)
P < 0.001Observational data: associations, not effects.
Secondary outcomes
Prevalence of CKM conditions
- at least 1 condition
- 85.5%
- all 3 conditions
- 22.3%
- Atherosclerotic cardiovascular disease (ASCVD)
- 58.7%
- Chronic kidney disease (CKD)
- 56.5%
- metabolic disorders
- 48.9%
Mortality and HF hospitalization alone
- Similar trends were observed for mortality and HF hospitalization alone
Original publication
Cardio-kidney-metabolic overlap in patients with severe heart failure: Data from the HELP-HF registry. Am Heart J. Published 3 June 2026. doi:10.1016/j.ahj.2026.107508
Summarised from the published abstract; every number is checked against it