Cardio-oncology & otherRandomised controlled trial
Cardio-Oncology Rehabilitation for Cancer Survivors With High Cardiovascular Risk
- Randomised controlled trial
- prospective
- single-centre
Authors' conclusion
The CORE trial showed that a cardio-oncology rehabilitation model among cancer survivors with high cardiovascular risk was associated with greater improvements in peak V̇o2 compared with usual care encompassing an exercise intervention in a community setting. The CBCR also showed superior results in exercise adherence, cardiovascular risk factor control, QOL, and health literacy.
Study context
- Population
- Adult cancer survivors with high CV risk (exposure to cardiotoxic cancer treatment and/or previous CVD)75 completed
- Participants
- 38 vs 37
- Comparison
- Center-based cardiac rehabilitation (CBCR) vs community-based exercise training (CBET)
- CBCRn = 38
- CBETn = 37reference
- Primary endpoint
- Change in peak V̇o2
- Follow-up
- 2 months
Primary result
As reported in the abstract
Mean difference
1.3 mL/kg/min
95% CI 0.1–2.6
P = 0.03
By group
CBCR vs CBET
mean difference 1.3 mL/kg/min (95% CI 0.1–2.6); P = 0.03
Secondary outcomes
Change in physical activity levels
P < 0.001
Change in QOL
P < 0.001
Change in health literacy score
P < 0.001
| Outcome | CBCR | CBET | P value |
|---|---|---|---|
| Change in SBP | mean −12.3 (SD 11.8) mm Hg | mean −1.9 (SD 12.9) mm Hg | P < 0.001 |
| Change in DBP | mean −5.0 (SD 5.7) mm Hg | mean −0.5 (SD 7.0) mm Hg | P = 0.003 |
| Change in BMI | mean −1.2 (SD 0.9) | mean 0.2 (SD 0.7) | P < 0.001 |
| Exercise adherence (sessions completed) | mean 90.3% (SD 11.8%) | mean 68.4% (SD 22.1%) | P < 0.001 |
Original publication
Cardio-Oncology Rehabilitation for Cancer Survivors With High Cardiovascular Risk. JAMA Cardiol. Published 1 December 2023. doi:10.1001/jamacardio.2023.3558
Summarised from the published abstract; every number is checked against it