Cardiometabolic & kidneyCohort study
Cardiometabolic and Atherosclerotic Cardiovascular Disease (ASCVD) Risk Profiles in Arab Americans
- Registry analysis
- Houston Methodist Cardiovascular Disease Learning Health System Registry (2016-2025)
- validated Arab name algorithm
- multivariable logistic regression, including sex-stratified models
Authors' conclusion
Arab American adults demonstrated substantial cardiometabolic and ASCVD burden, with premature ASCVD characterized by clustering of hyperlipidemia, hypertension, smoking, and elevated body mass index. These findings support improved ethnicity data collection, and earlier, more intensive risk-factor management in this under-recognized population.
Study context
- Population
- Arab American adults ≥18 years in a large U.S. health care systemArab American adults (53.1% women, median age, 44 years)
- Participants
- 49,440 adults
- Exposure
- Associations of traditional risk factors with overall and premature ASCVD
Main finding
As reported in the abstract
ASCVD and premature ASCVD prevalence
ASCVD
15.2%
Premature ASCVD
3.4%
Observational data: associations, not effects.
Further findings
Risk factor associations with ASCVD
| Comparison | OR (95% CI) | |
|---|---|---|
| Hyperlipidemia · ASCVD · Strongest correlates of ASCVD | 3.36 (3.13–3.61) | |
| Hypertension · ASCVD · Strongest correlates of ASCVD | 3.14 (2.91–3.39) | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | OR |
|---|---|
| Risk factor associations with ASCVD — Hyperlipidemia · premature ASCVD · Strongest correlates of ASCVD | 4.18 |
| Risk factor associations with ASCVD — Hypertension · premature ASCVD · Strongest correlates of ASCVD | 3.88 |
Cardiometabolic conditions by age and sex
- Cardiometabolic conditions increased with age and were more prevalent in men, except for obesity
Sex-stratified associations with premature ASCVD
- Hyperlipidemia was more strongly associated with premature ASCVD in men, whereas hypertension and diabetes showed stronger associations in women
Original publication
Cardiometabolic and ASCVD Risk Profiles in Arab Americans. JACC Adv. Published 2 September 2026. doi:10.1016/j.jacadv.2026.103202
Summarised from the published abstract; every number is checked against it