Cardio-oncology & otherCohort study
Cardiometabolic factors’ and cardiovascular risk in young adult cancer survivors: evidence from real-world data
- Retrospective cohort study
- matched 1:1 on sex and year of birth
Authors' conclusion
Cardiometabolic factors independently contribute to elevated CVD risk in YA cancer survivors, beyond the effects of cancer treatment alone.
Study context
- Population
- Young adult cancer survivors (diagnosed age 19–39 years, ≥2-year survivorship), University of California, Irvine electronic medical records
- Participants
- 8,943 young adult (YA) cancer survivors
- Exposure
- YA cancer survivors vs Non-cancer
- YA cancer survivorsn = 8,943
- Outcome
- CVD outcomes: stroke, myocardial infarction (MI) and congestive HF
Main finding
As reported in the abstract
Associations of cardiometabolic factors with CVD in cancer survivors (adjusted)
Each group vs non-cancerOdds ratio (95% CI)
T2DMMI
6.99(3.45–14.19)
T2DMCHF
12.304(7.23–20.91)
HypertensionCHF
20.48(11.79–35.57)
Observational data: associations, not effects.
Further findings
Prevalence of cardiometabolic factors
- More prevalent in cancer survivors than non-cancer participants, with racial/ethnic disparities
Original publication
Cardiometabolic factors’ and cardiovascular risk in young adult cancer survivors: evidence from real-world data. Eur J Prev Cardiol. Published 12 August 2025. doi:10.1093/eurjpc/zwaf517
Summarised from the published abstract; every number is checked against it