Heart failure & cardiomyopathiesCohort study
Cardiopulmonary exercise testing in hypertrophic cardiomyopathy: the role of reduced O2 pulse and chronotropic incompetence in myocardial adaptation
- Prospective cohort study
- multicentre
Authors' conclusion
SV and O2p are significantly related, and the RoMa classification effectively distinguished HCM patients.
Study context
- Population
- Clinically stable hypertrophic cardiomyopathy (HCM) patients undergoing cardiopulmonary exercise testing with impedance cardiography
- Participants
- 90 patients
- Exposure
- RoMa classes I–IV by peak HR and peak O2 pulse
- Outcome
- Relationship between SV and O2 pulse (O2p)
Main finding
As reported in the abstract
SV vs O2p
Correlation stroke volume (SV)–oxygen pulse (O2p) (r)
r = 0.48, P < 0.001
Regression SV on O2p (β)
β = 3.59, P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | RoMa I | RoMa II | RoMa III | RoMa IV |
|---|---|---|---|---|
| Peak VO2 across RoMa classes | mean 29.7 (SD 8.3) mL/min/kg | Not reported in the abstract | Not reported in the abstract | mean 16.2 (SD 5.1) mL/min/kg |
| VE/VCO2 slope across RoMa classes | mean 26.4 (SD 4.5) | Not reported in the abstract | Not reported in the abstract | mean 38.6 (SD 6.0) |
| Peak SV across RoMa classes | mean 128.7 (SD 24.8) mL | Not reported in the abstract | Not reported in the abstract | mean 104.7 (SD 28.0) mL |
| Rest-to-peak SV difference | median 38.6 (IQR 30.4–52.8) mL | Not reported in the abstract | Not reported in the abstract | median 15.8 (IQR 8.2–27.9) mL |
| Resting moderate to severe MR | 18% | Not reported in the abstract | Not reported in the abstract | 41% |
- Peak VO2 across RoMa classes: P < 0.001
- VE/VCO2 slope across RoMa classes: P = 0.002
- Peak SV across RoMa classes: P = 0.019
- Rest-to-peak SV difference: P = 0.002
- Resting moderate to severe mitral regurgitation (MR): P = 0.038
Original publication
Cardiopulmonary exercise testing in hypertrophic cardiomyopathy: the role of reduced O2 pulse and chronotropic incompetence in myocardial adaptation. Eur J Prev Cardiol. Published 7 August 2025. doi:10.1093/eurjpc/zwaf402
Summarised from the published abstract; every number is checked against it