Heart failure & cardiomyopathiesCase-control study
Cardiopulmonary exercise testing parameters in healthy athletes vs. equally fit individuals with hypertrophic cardiomyopathy
- Matched case-control study
- single-centre
- matched (2:1 ratio) for age, sex, height, weight and ppV˙O2
Authors' conclusion
Even in the setting of similar and supranormal pV˙O2, ventilatory efficiency is worse in HCM participants vs. healthy athletes.
Study context
- Population
- Individuals with non-obstructive hypertrophic cardiomyopathy (HCM) and matched healthy athletes undergoing cycle ergometer cardiopulmonary exercise testing (CPET)matched 2:1
- Participants
- 30 vs 60
- Comparison
- HCM vs healthy athletes
- HCMn = 30
- Athletesn = 60reference
- Outcome
- Ventilatory efficiency and recovery kinetics on CPET
Main finding
As reported in the abstract
Ventilatory efficiency (abnormally high V˙E/V˙CO2 nadir >30; early V˙E/V˙CO2 slope; V˙E/V˙CO2 nadir; end-tidal CO2 at ventilatory threshold)
HCM vs Athletes: P = 0.02 · HCM vs Athletes: P = 0.02 · HCM vs Athletes: P = 0.004 · HCM vs Athletes: P = 0.02
Observational data: associations, not effects.
Further findings
Peak oxygen consumption (pV˙O2)
% predicted HCM 125 ± 26 · Athletes 124 ± 25
Peak oxygen consumption (pV˙O2)
- Similar, supranormal pV˙O2 (consistent with matching)
Original publication
Cardiopulmonary exercise testing parameters in healthy athletes vs. equally fit individuals with hypertrophic cardiomyopathy. Eur J Prev Cardiol. Published 5 May 2025. doi:10.1093/eurjpc/zwaf177
Summarised from the published abstract; every number is checked against it