Heart failure & cardiomyopathiesCohort study
Cardiopulmonary Performance Among Heart Failure Patients Before and After Left Ventricular Assist Device Implantation
- Prospective longitudinal study
- invasive cardiopulmonary exercise testing
- pulmonary artery catheterization
Authors' conclusion
Among patients with HFrEF, cardiovascular hemodynamics and exercise capacity were similar after CF-LVAD implantation, regardless of whether patients exercised at fixed or adjusted pump speeds during exercise.
Study context
- Population
- Patients with heart failure with reduced ejection fraction (HFrEF) undergoing continuous-flow left ventricular assist device (CF-LVAD) implantationcrossover: each patient in every visit
- Participants
- 10 patients
- Exposure
- Before vs after CF-LVAD implantation
Main finding
As reported in the abstract
Maximal oxygen uptake
- Did not improve after device implantation
- P = 0.92
Observational data: associations, not effects.
Further findings
Mean pulmonary arterial and pulmonary capillary wedge pressures
- Increased significantly during submaximal and peak exercise before implantation (rest vs peak exercise)
- P < 0.01
- Remained elevated, minimal change on Visits 2 and 3 whether pump speed fixed or increased
Original publication
Cardiopulmonary Performance Among Heart Failure Patients Before and After Left Ventricular Assist Device Implantation. JACC Heart Fail. Published 23 August 2023. doi:10.1016/j.jchf.2023.06.017
Summarised from the published abstract; every number is checked against it